Synthesis of Chemically Bonded Cellulose Trisphenylcarbamate Chiral Stationary Phases for Enantiomeric Separation

Capillary electrochromatographic separation of enantiomers under aqueous mobile phases on a covalently bonded cellulose derivative chiral stationary phase.

A chemically bonded cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase (CSP) was prepared by a radical polymerization reaction. The prepared CSP was packed into fused-silica capillaries with inner diameter of 75 microm to perform enantiomer separations in CEC. The electrochromatographic behavior of the CSP was investigated. On the prepared CSP, high EOF could be generated under...

A validated chiral LC method for enantiomeric separation of intermediate of lopinavir by using cellulose based chiral stationary phase

2R-(1-Tetrahydro pyrimid-2-onyl)-3-methyl butanoic acid. (STHPA) (Figure 1) is a intermediate for Lopinavir (Figure 2). Lopinavir is antiretroviral drugs acting as inhibitors of human immunodeficiency virus (HIV) protease, a class of drugs that has markedly improved morbidity and mortality of HIV infected patients[1]. Within the highly active antiretroviral therapy (HAART) they are used in a f...

The Development and Application of Cellulose- Based Stationary Phases in Stereoselective Separation of Chiral Pesticides

Chapter2 Synthesis and Characterization of Amide Bonded Polymeric Stationary Phases

Novel polymeric stationary phases based on amberlite XAD-4 has been synthesized. Functionalized polymers are obtained by reactions, which involves Friedel-Crafts acetylation, oxidation and chloroformoylation of the resin. These functionalized polymers were reacted with chiral selector viz. R(+)-1-phenylethylamine and amino acid viz. methyl ester L-histidine dihydrochloride via Schotten Baumann ...

Review High-performance liquid chromatographic enantioseparation of drugs containing multiple chiral centers on chiral stationary phases

In recent years there has been considerable interest in the synthesis and separation of enantiomers of organic compounds especially because of their importance in the biochemistry and pharmaceutical industry. High-performance liquid Chromatography is a very useful method for the direct separation of enantiomers. However, about 30−40 years ago, commercially available chiral stationary phases wer...